Uncle John Joad

Older brother of Pa Joad, feels responsible for the death of his young wife years before when he ignored her pleas for a doctor because he thought she just had a stomachache. Filled with guilt, he is prone to binges involving booze and prostitutes.

Jim Casy — A former preacher who lost his faith after fornicating with willing members of his church numerous times, and from his perception that religion has no solace or answer for the difficulties the people are experiencing Jingling the change in his hand he shook his head. He is a Christ figure and shares his initials with Jesus.

Al Joad — The second youngest son who cares mainly for cars and girls; looks up to Tom, but begins to find his own way.

Rose of Sharon Joad Rivers — Childish and dreamy teenage daughter who develops as the novel progresses to become a mature woman. She symbolizes regrowth when she helps the starving stranger (see also Roman Charity, works of art based on the legend of a daughter as wet nurse to her dying father). Pregnant in the beginning of the novel, she delivers a stillborn baby, probably as a result of malnutrition. Her name is pronounced "Rosasharn" by the family.

Connie Rivers — Rose of Sharon's husband. Young and naive, he is overwhelmed by the responsibilities of marriage and impending fatherhood, and abandons her shortly after arriving in California. He is stated to be 19 years old upon his and Tom's first encounter before leaving for California.

Noah Joad — The oldest son who is the first to willingly leave the family, choosing to stay by an idyllic river and survive by fishing. Injured at birth, described as "strange", he may have slight learning difficulties or autistic spectrum disorder.

Grampa Joad — Tom's grandfather who expresses his strong desire to stay in Oklahoma. His full name is given as "William James Joad". Grampa is drugged by his family with "soothin' syrup" to force him to leave but dies shortly after of a stroke.

Granma Joad — The religious wife of Grampa Joad, she seems to lose the will to live (and consequently dies while crossing the desert) after her husband's death.

Ruthie Joad — The youngest daughter, age twelve.

Winfield Joad — The youngest male in the family, aged ten. He and Ruthie are close.

Muley Graves - A neighbor of the Joads, he is offered to come along to California with them but refuses. Two of the family dogs are left in his care, while the third goes along with the family and Casy(and is killed by a car on the road when they stop for gas).